Institut Pasteur (IP)

The Institut Pasteur (IP) is an internationally renowned centre for biomedical research with a network of 33 institutes worldwide. Institut Pasteur operates in four main areas: scientific and medical research, public health and health monitoring, teaching, business development and technology transfer. The Institut Pasteur is a global leader in infectious diseases, microbiology, and immunology with the goal to expand our knowledge of living organisms in a bid to lay the foundation for new prevention strategies and novel therapeutics. Since its inception, 10 scientists have been awarded the Nobel Prize for Medicine, and play a major role in activities that directly benefit patients.

Darragh Duffy leads the Translational Immunology Lab within the Immunology Department that aims to better understand inter-individual differences in immune responses, and apply these discoveries to relevant clinical questions. They use cellular mechanistic models, population immunology cohorts, and experimental clinical studies in infection and autoimmunity and work closely with clinicians to help develop new patient management systems. This laboratory has also played a leading role in the establishment of the LabEx Milieu Intérieur project, which has provided an initial assessment of healthy donor reference values for microbe-induced cytokines and chemokines and quantified the major genetic and intrinsic contributors to immune response variability. This laboratory is now focused on the deconvolution of the healthy immune response, and applying these approaches for a better understanding of perturbed immune responses in infection, autoimmunity and variable responses to immunotherapy and vaccination.

Main roles in project

Our main task will be to implement standardized immune monitoring strategies to deeply characterize baseline immune responses and test the hypothesis that induced immune responses prior to vaccination can be used to model and ultimately predict vaccine responsiveness. 

Contact: Dr. Darragh Duffy